How to Slow Aging (and even reverse it)

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  • Published on:  Saturday, December 14, 2019
  • Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.
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    What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.

    To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.

    Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.

    Special thanks to:
    Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To"
    Assistant Professor David Gold
    Noemie Sierra (for polyp images)
    Genepool Productions for telomere animations from Immortal:
    Epigenetics animations (DNA, histones, methylation etc) courtesy of:
    Animation: Etsuko Uno
    Art and Technical Direction: Drew Berry
    Sound Design: Francois Tetaz & Emma Bortignon
    Scientific Consultation: Marnie Blewitt
    Courtesy of Walter and Eliza Hall Institute of Medical Research

    Filming, editing and animation by Jonny Hyman and Derek Muller

    Music from "Clearer Views" "Innovations" "A Sound Foundation" "Seaweed"
    Additional music by Kevin MacLeod from "Marty Gots a Plan"


  • Alt Name
    Alt Name  10 minutes ago


    Learn about Sauna.

    Sauna reverses much of this.

    DINAL LA  an hour ago

    14:14 Usain Bolt enter the chat

  • ChipperSpice
    ChipperSpice  2 hours ago

    30 years from now David Sinclair will look the same.

  • Shreshth Sharma
    Shreshth Sharma  10 hours ago

    Better die with malnutrition

  • Darth Maul
    Darth Maul  16 hours ago +1

    will this help my dog live longer

  • jayknight139
    jayknight139  22 hours ago +1

    Yay the future!

  • Brainism Thoughtism

    AFRICANS under Normal Conditions DO Live longer and Healthier Lives due to their Melanin  {as Westerners already KNOWS but refused to Acknowledge for Racist/Political Reasons}  While the Blacks that are living on unhealthy Western Non-traditionally-Africa diets are the ones experiencing such Age-Related ailments, which Westerners DOES like to acknowledge and use as their  ONE-UP for whites Over ALL Blacks.   ….Albeit quite hypocritical, it's nonetheless their Race War being fight against Black People!

    by the way, Galega officinalis is Native to the continent of Africa, after being taught of its use by the Africans to the French, it was then replanted on the French continent and claimed by the French as if it was their own, like everything else stolen and plagiarized from Africa!

  • thegercius
    thegercius  yesterday

    Brain cell " I identify as a skin cell"
    David Sinclair "Not so fast"
    SJW cells "Omg it's that right wing fascist scientist again"

  • Maga Man
    Maga Man  yesterday

    I dunno about all this, monks and nuns that used to live in austere monasteries and cloisters over the centuries didn't live any longer than the general population. Besides, Professor Sinclair doesn't look anywhere near his claimed biological age of 31, he looks more like his real age - at least on my 4K screen.

  • Justin Koenig
    Justin Koenig  yesterday

    Good 'ol irreproducible research

  • Streeknine
    Streeknine  yesterday

    Holy crap! He's done it boys! He's found the reverse aging formula and using it on himself! :O
    Listen closely at 8:56 as he describes he's "50 but might be biologically 60, actually I was. And uh, (I changed my life) and then the test said I was biologically 31".

  • Streeknine
    Streeknine  yesterday +1

    60 years from now, another journalist interviews Prof Sinclair and he tells the journalist, "We are close to figuring out reverse aging, but we aren't quite there yet "

  • Levizja per dije
    Levizja per dije  yesterday +1

    Mystery should be 20 again.
    The pickup artist, more girls for him.

  • Nevermore
    Nevermore  2 days ago

    As for overpopulation... that's not much of a concern in the developed world where birth rates are largely flat-lined if not too low such as countries in NE Asia, Europe, etc.
    Those countries could use extended aging without much, if any societal concern. Regions like India, Africa, etc just need to reduce their birth rates before they could access anti-aging drugs as they would see even worse degradation of their societies, more-so than overpopulation has already wreaked there.

  • Nevermore
    Nevermore  2 days ago

    Yeah... especially when governments want to stall on social security payments until you're nearly 70... for many people that's on the brink of death before they can retire.

  • Tha Ruckus
    Tha Ruckus  2 days ago

    Research: Nun Amen-Ra
    This scientist already figured this out 15+ years ago and adopted a regimen that includes intermittent fasting and caloric restriction. This man is a BEAST! And looks very young for his age

  • panoshanos1
    panoshanos1  2 days ago

    do we need to reverse the whole body at once? why not use it as therapy for broken down parts of the body?

  • HHO Philippines
    HHO Philippines  2 days ago

    put me on the list

  • Samiyuru Senarathne

    9:04 What is the change that Prof Sinclair made to his life?

  • Adam M
    Adam M  2 days ago

    It's not that this is too good to be true. It's too good not to attract conmen. Sinclair is a scientist and thanks in part to his ability to sell, also a rich one. I'll be more satisfied he's an honest one when we see a lot of study replication.